10-3937
ML382
Size
£182.00
- SKU:
- 10-3937
- Additional Names:
- 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide|VU0485891
- Physical State:
- Solid
- Molecular Weight:
- 360.43
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1646499-97-9
- Immunogen:
- GPCR
- Extra Details:
- ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2
- Shipping Conditions:
- Ambient