10-3928
MRTX849
Size
£163.00
- SKU:
- 10-3928
- Additional Names:
- Adagrasib
- Physical State:
- Solid
- Molecular Weight:
- 604.13
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2326521-71-3
- Immunogen:
- GTPase
- Extra Details:
- MRTX849 is a potent (IC50's = 14 nM NCI-H358; 5 nM MIA PaCa-2) and selective (over 463 proteins @ 1 uM) covalent KRASG12C inhibitor.1 It showed pronounced tumor regression in 17 of 26 KRASG12C-positive cell lines and xenograft models from multiple tumor types.2 MTRTX849 reversed the immunosuppressive tumor environment in a genetically modified mouse model and sensitized tumors to checkpoint inhibitor therapy in a genetically modified mouse KRASG12C lung adenocarcinoma model.3 It reversed ABCB1-mediated multidrug resistance in vitro and in vivo via attenuating ABCB1 efflux in drug-resistant cancer cells.4
- Shipping Conditions:
- Ambient