10-3924
PY-60
Size
£173.00
- SKU:
- 10-3924
- Physical State:
- Solid
- Molecular Weight:
- 313.38
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 2765218-56-0
- Immunogen:
- Transcription factor
- Extra Details:
- PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 uM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2
- Shipping Conditions:
- Ambient