10-3923
CIB-3b
Size
£153.00
- SKU:
- 10-3923
- Physical State:
- Solid
- Molecular Weight:
- 261.28
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 124811-87-6
- Immunogen:
- RNA
- Extra Details:
- CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 uM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
- Shipping Conditions:
- Ambient