10-3893
Baricitinib
Size
£147.00
- SKU:
- 10-3893
- Additional Names:
- INCB028050|LY3009104
- Physical State:
- Solid
- Molecular Weight:
- 371.42
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1187594-09-7
- Immunogen:
- Kinase
- Extra Details:
- Baricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 uM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome ("cytokine storm") induced by SARS-CoV-2 infection.3
- Shipping Conditions:
- Ambient