10-3756
NOTUMib-1
Size
£153.00
- SKU:
- 10-3756
- Physical State:
- Solid
- Molecular Weight:
- 292.33
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- Extra Details:
- NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 M, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.
- Shipping Conditions:
- Ambient