10-3576
Canagliflozin
Size
£149.00
- SKU:
- 10-3576
- Additional Names:
- JNJ-24831754
- Physical State:
- Solid
- Molecular Weight:
- 444.52
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 842133-18-0
- Immunogen:
- Glucose transporter
- Extra Details:
- Potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM selective over SGLT1, IC50=910 nM.1 Dose dependently increases glucose excretion in healthy subjects.2 Displays beneficial effects in nonalcoholic fatty liver disease (NAFLD).3 Extends lifespan in male but not female mice.4 Inhibits cancer cell proliferation via inhibition of mitochondrial complex-1 supported respiration.5 Suppresses the growth of pancreatic cancer cells.6
- Shipping Conditions:
- Ambient