10-3564
Verrucarin A
Size
£226.00
- SKU:
- 10-3564
- Additional Names:
- 379-Y|Glutinosin-I|Muconomycin-A|Myrothecin-I|NSC-126728
- Physical State:
- Solid
- Molecular Weight:
- 502.56
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 3148-09-2
- Immunogen:
- Transcription factor
- Extra Details:
- A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFA Alpha-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREA Alpha and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
- Shipping Conditions:
- Ambient