10-3556
Gramicidin A
Size
£134.00
- SKU:
- 10-3556
- Additional Names:
- Peptide fermentation product isolated from B brevis
- Physical State:
- Solid
- Molecular Weight:
- 1882.29
- Purity:
- >95%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 11029-61-1
- Immunogen:
- Antibiotic|Ionophore|RNA
- Extra Details:
- Gramicidin A (11029-61-1) is a hydrophilic non-ribosomal peptide ionophore that forms channels in membranes which are monovalent cation-permeable.1,2 Disruption of cellular ionic homeostasis is the basis for its antibiotic activity.3 It is also cytotoxic to a variety of cancer cell lines4 and tumor xenografts5. Gramicidin A was shown to stimulate melanoma differentiation-associated protein 5 (MDA5)-mediated IFN signaling by enhancing its oligomerization onto RNA and thus represents a new tool to manipulate MDA5 activity.6
- Shipping Conditions:
- Ambient