AA43279

Size

£158.00

SKU:: 10-3503
Physical State:: Solid
Molecular Weight:: 248.30
Purity:: 97%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 354812-16-1
Immunogen:: Ion channel
Extra Details:: Selective Nav1.1activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 uM). In rat hippocampal brain slices it increased the firing activity parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1