10-3484
Streptonigrin
Size
£224.00
- SKU:
- 10-3484
- Additional Names:
- Bruneomycin|NSC-45383
- Physical State:
- Solid
- Molecular Weight:
- 506.47
- Purity:
- >95%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 3930-19-6
- Immunogen:
- Protease
- Extra Details:
- Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1A Alpha.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
- Shipping Conditions:
- Ambient