10-3385
RITA
Size
£168.00
- SKU:
- 10-3385
- Additional Names:
- NSC 652287
- Physical State:
- Solid
- Molecular Weight:
- 292.37
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 213261-59-7
- Immunogen:
- Ribosome|Transcription factor
- Extra Details:
- RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 uM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2A Alpha phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
- Shipping Conditions:
- Ambient