10-3382
CLP-3094
Size
£163.00
- SKU:
- 10-3382
- Physical State:
- Solid
- Molecular Weight:
- 304.79
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 312749-73-8
- Immunogen:
- GPCR
- Extra Details:
- GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 M against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3
- Shipping Conditions:
- Ambient