10-3320
Nintedanib
Size
£144.00
- SKU:
- 10-3320
- Additional Names:
- BIBF-1120
- Physical State:
- Solid
- Molecular Weight:
- 539.64
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 656247-17-5
- Immunogen:
- Kinase
- Extra Details:
- Nintedanib is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4
- Shipping Conditions:
- Ambient