10-3231
Cabozantinib
Size
£149.00
- SKU:
- 10-3231
- Additional Names:
- BMS-907351|Carbozantinib|XL-184
- Physical State:
- Solid
- Molecular Weight:
- 501.51
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 849217-68-1
- Immunogen:
- Kinase
- Extra Details:
- Novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 uM respectively.1 Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model.2 Clinically useful anticancer agent.3
- Shipping Conditions:
- Ambient