10-3075
Tolcapone
Size
£149.00
- SKU:
- 10-3075
- Additional Names:
- Ro 40-7592
- Physical State:
- Solid
- Molecular Weight:
- 273.24
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 134308-13-7
- Immunogen:
- Dopamine|Methyltransferase
- Extra Details:
- Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes.1 Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity.2 Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo.3 Inhibits O-methylation of exogenous polyphenols such as EGCG.4 Cell permeable. Orally bioavailable
- Shipping Conditions:
- Ambient