10-3055
Compound 401
Size
£168.00
- SKU:
- 10-3055
- Physical State:
- Solid
- Molecular Weight:
- 381.32
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 168425-64-7
- Immunogen:
- Kinase
- Extra Details:
- Compound 401 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), IC50s = 0.28 and 5.3 uM, respectively) with selectivity over PI3K, ATM, and ATR.1 Treatment of cells with 401 (10 uM) blocked the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr(389) and Akt Ser(473), respectively) with no direct inhibition of Akt Thr(308) phosphorylation, which is dependent on PI3K.2
- Shipping Conditions:
- Ambient