10-3005
MDL-28170
Size
£147.00
- SKU:
- 10-3005
- Additional Names:
- Calpain Inhibitor III|Z-Val-Phe-CHO
- Physical State:
- Solid
- Molecular Weight:
- 382.45
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 88191-84-8
- Immunogen:
- Protease
- Extra Details:
- A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1 It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2 Displays neuroprotective effects in neurotrama rodent models.3 Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0.3 uM in intact cell assay.4
- Shipping Conditions:
- Ambient