Embelin

Size

£153.00

SKU:: 10-2959
Physical State:: Solid
Molecular Weight:: 294.39
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 550-24-3
Immunogen:: Acetyltransferase
Extra Details:: Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 uM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 uM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.