10-2928
PLX-4032
Size
£139.00
- SKU:
- 10-2928
- Additional Names:
- R7204|Ro 51-85426|Vemurafenib
- Physical State:
- Solid
- Molecular Weight:
- 489.92
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 918504-65-1
- Immunogen:
- Kinase
- Extra Details:
- An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4
- Shipping Conditions:
- Ambient