Safinamide

Size

£147.00

SKU:: 10-2924
Additional Names:: FCE-26743|NW-1015|PNU-151774E
Physical State:: Solid
Molecular Weight:: 302.34
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 133865-89-1
Immunogen:: Dopamine|Monoamine oxidase|Serotonin
Extra Details:: A selective and reversible inhibitor of monoamine oxidase B (MAO-B, IC50=98 nM with greater than 100-fold selectivity over MAO-A.1 Displays anticonvulsant activity2 and protects against kainate-induced seizures and hippocampal neurodegeneration in rat models3. Reduces overactive glutamatergic signaling via use-dependent sodium channel blockade.4 A novel therapeutic for Parkinson's disease with multiple modes of action.5 Effective as an add-on to dopamine agonist therapy in early Parkinson's.6