10-2826
Ethacrynic acid
Size
£158.00
- SKU:
- 10-2826
- Additional Names:
- MK-595|NSC-85791
- Physical State:
- Solid
- Molecular Weight:
- 303.14
- Purity:
- >99%
- Purification:
- HPLC Purified
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 58-54-8
- Immunogen:
- Glutathione
- Extra Details:
- Ethacrynic acid (58-54-8) was found to be an inhibitor of glutathione transferase P1-1 (GST P1-1) in a screen of FDA-approved drugs. It inhibits both GST P1-1 and A3-1, IC50s=4.9 and 0.4 uM respectively and apparently acts as an allosteric inhibitor.1 It forms conjugates with glutathione which also inhibit GST competitively.2 Ethacrynic acid is cytotoxic to a number of cancer cells3 and synergizes with anticancer agents like afatinib4. It is a clinically useful diuretic agent.5
- Shipping Conditions:
- Ambient