10-2768
Pomalidomide
Size
£149.00
- SKU:
- 10-2768
- Additional Names:
- 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
- Physical State:
- Solid
- Molecular Weight:
- 273.24
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 19171-19-8
- Immunogen:
- Molecular glue|Ubiquitin ligase
- Extra Details:
- Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
- Shipping Conditions:
- Ambient