Probucol

Size

£197.00

SKU:: 10-2679
Additional Names:: DH-581
Physical State:: Solid
Molecular Weight:: 516.84
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 23288-49-5
Immunogen:: Antioxidant|Inflammasome
Extra Details:: Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1)-mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6