10-2615
Splitomicin
Size
£153.00
- SKU:
- 10-2615
- Physical State:
- Solid
- Molecular Weight:
- 198.22
- Purity:
- 98%
- Storage Conditions:
- RT
- Supplier:
- Focus Biomolecules
- CAS Number:
- 5690-03-9
- Immunogen:
- Protein deacetylase
- Extra Details:
- Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.
- Shipping Conditions:
- Ambient