10-2534
AM-80
Size
£149.00
- SKU:
- 10-2534
- Additional Names:
- NSC608000|Retinobenzoic acid|Tamibarotene
- Physical State:
- Solid
- Molecular Weight:
- 351.45
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 94497-51-5
- Immunogen:
- Retinoid receptor and related|Transcription factor
- Extra Details:
- AM80 (94497-51-5) is a retinoic acid receptor A Alpha (RARA Alpha) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells.1 Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 uM respectively).2 It ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17.3 AM80 induces neuronal differentiation in a human neuroblastoma NH-12 cell line.4 Pulmonary administration of AM80 regenerates collapsed alveoli.5
- Shipping Conditions:
- Ambient