10-2484
Rocaglamide
Size
£197.00
- SKU:
- 10-2484
- Additional Names:
- RocA
- Physical State:
- Solid
- Molecular Weight:
- 505.57
- Purity:
- 97%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 84573-16-0
- Extra Details:
- Rocaglamide is a potent inhibitor of NFkB in T-lymphocytes with almost complete inhibition at 200nM.1 It was able to completely inhibit IL-4 and IFN-G Gamma production and suppress 60-85% of IL-2 and TNF-A Alpha production at 50nM in T-cells without inhibiting AP-1 and NF-kB (conversely, at concentrations <100nM, it was shown to increase NF-kB activity).2 Immunosuppression activity was due to inhibition of cytokine gene expression via blocking of NF-AT activity and is a different mechanism than suppression via Cyclosporine a and FK-506. Rocaglamide has anti-cancer properties via various pathways including ERK inhibition3, ATM/ATR-Chk1/Chk2 activation4, and p38 and JNK activation5.
- Shipping Conditions:
- Ambient