10-2434
Mizoribine
Size
£153.00
- SKU:
- 10-2434
- Additional Names:
- NSC-289637
- Physical State:
- Solid
- Molecular Weight:
- 259.22
- Purity:
- >98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 50924-49-7
- Immunogen:
- HSP (Heat shock protein)
- Extra Details:
- Mizoribine is an immunosuppressant nucleoside natural product first isolated from Eupenicillium brefeldianum.1 Inhibits inosine monophosphate dehydrogenase, suppressing T-cell proliferation via depletion of guanine ribonucleotides.2 Reduces cellular GTP levels in CEM leukemia cells (68% at 4 mM and 2 hours).3 Selectively attenuates the expression of monocyte chemoattractant protein 1.4 Mizoribine also acts at HSP60, and induces an HSP60/HSP10 complex which consequently suppresses IL-6 expression.5 It displays anti-proteinuric effects by restoring normal nephrin biogenesis in nephrotic syndrome models.6
- Shipping Conditions:
- Ambient