Veliparib 2HCl

Size

£149.00

SKU:: 10-2419
Additional Names:: ABT-888
Physical State:: Solid
Molecular Weight:: 317.22
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 912445-05-7
Immunogen:: PARP
Extra Details:: Potent and selective PARP-inhibitor with Ki values of 5.2 nM and 2.9 nM for PARP-1 and PARP-2, respectively.1 Restores sensitivity to DNA alkylator/methylator temozolomide in glioma cells and xenografts2, and enhances radiotherapy sensitivity in endometrial carcinoma cells3. Also improves sensitivity to DNA replication inhibitor cisplatin in human oral carcinoma cells.4