10-2386
B Beta-Lapachone
Size
£151.00
- SKU:
- 10-2386
- Additional Names:
- NSC-26326
- Physical State:
- Solid
- Molecular Weight:
- 242.27
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 4707-32-8
- Immunogen:
- DNA|Topoisomerase
- Extra Details:
- A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
- Shipping Conditions:
- Ambient