10-2280
L-Cycloserine
Size
£149.00
- SKU:
- 10-2280
- Additional Names:
- L-(-)-Cycloserine|S-Cycloserine
- Physical State:
- Solid
- Molecular Weight:
- 102.09
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 339-72-0
- Extra Details:
- L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase).1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
- Shipping Conditions:
- Ambient