Picropodophyllotoxin

Size

£177.00

SKU:: 10-2189
Physical State:: Solid
Molecular Weight:: 414.42
Purity:: 97%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 477-47-4
Immunogen:: Cytoskeleton|Kinase
Extra Details:: Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP1. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM1. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 M2. Exhibits antiangiogenic activitiy3. Attenuates intimal hyperplasia after vascular injury4. Active in vivo.