10-2182
Vismodegib
Size
£158.00
- SKU:
- 10-2182
- Additional Names:
- GDC-0449
- Physical State:
- Solid
- Molecular Weight:
- 421.30
- Purity:
- 99%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 879085-55-9
- Immunogen:
- GPCR
- Extra Details:
- A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2 Inhibits two ABC transporters, ABCG2/BCRP and ABCB1/Pgp, IC50s=1.4 and 3.0 uM respectively.3 Clinically useful for the treatment of basal cell carcinoma.4 Inhibits proliferation and induces apoptosis in colon cancer cell lines.
- Shipping Conditions:
- Ambient