10-2180
ZSTK474
Size
£147.00
- SKU:
- 10-2180
- Physical State:
- Solid
- Molecular Weight:
- 417.41
- Purity:
- 99%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 475110-96-4
- Immunogen:
- Kinase
- Extra Details:
- Novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3KD Delta most potently, with a Ki of 1.8 nM, while inhibiting the A Alpha, B Beta and G Gamma isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively)1. Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice2. It displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis3. Ameliorates the progression of adjuvant-induced arthritis in a rat model4.
- Shipping Conditions:
- Ambient