10-2162
Pemetrexed
Size
£168.00
- SKU:
- 10-2162
- Additional Names:
- LY231514
- Physical State:
- Solid
- Molecular Weight:
- 597.49
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 357166-29-1
- Immunogen:
- DNA|RNA
- Extra Details:
- Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 uM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 uM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5
- Shipping Conditions:
- Ambient