10-2158
Pazopanib
Size
£139.00
- SKU:
- 10-2158
- Additional Names:
- GSK-VEG10003|GW786034B
- Physical State:
- Solid
- Molecular Weight:
- 437.52
- Purity:
- >98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 444731-52-6
- Immunogen:
- Kinase
- Extra Details:
- Inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRA Alpha, B Beta and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR.1 The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma.2 It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models.3 VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration.4 In clinical use for renal cell carcinoma.5
- Shipping Conditions:
- Ambient