Lenalidomide

Size

£173.00

SKU:: 10-2148
Additional Names:: CC-5013
Physical State:: Solid
Molecular Weight:: 259.26
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 191732-72-6
Immunogen:: Molecular glue|Ubiquitin ligase
Extra Details:: Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic