Bexarotene

Size

POA

SKU:: 10-2121
Additional Names:: LGD-1069|SR-11247
Physical State:: Solid
Molecular Weight:: 348.49
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 153559-49-0
Immunogen:: Retinoid receptor and related|Transcription factor
Extra Details:: A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRA Alpha, B Beta, G Gamma respectively)1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma2 Causes complete regression of mammary carcinoma3. Bexarotene significantly increases clearance of soluble B Beta-amyloid in a mouse Alzheimer's model and increases cognitive ability4. Reverses apoE4-driven brain pathology and behavioral deficits in vivo5.