Myriocin (ISP-1)

Size

£156.00

SKU:: 10-2088
Additional Names:: ISP-1
Physical State:: Solid
Molecular Weight:: 401.54
Purity:: >98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 35891-70-4
Immunogen:: Antibiotic
Extra Details:: Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3