Cerulenin

Size

£216.00

SKU:: 10-2062
Physical State:: Solid
Molecular Weight:: 223.27
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 17397-89-6
Immunogen:: Acyltransferase|Antibiotic
Extra Details:: Fatty acid synthase (FAS) inhibitor. Binds to B Beta-keto-acyl-ACP synthase (KAS; IC50=1.5 uM), thus inhibiting protein acylation at concentrations of 45-134 uM1. Produces metabolic effects similar to the effects of leptin, but through mechanisms that are independent of, or down-stream of, both leptin and melanocortin receptors2. Reduces nutrient-induced insulin release from normal rat islets3. Induces apoptosis in human melanoma A-375 cells4.