10-2047
DRB
Size
£134.00
- SKU:
- 10-2047
- Additional Names:
- 5,6-Dichlorobenzimidazole riboside|NSC 401575
- Physical State:
- Solid
- Molecular Weight:
- 319.14
- Purity:
- 98%
- Purification:
- HPLC Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 53-85-0
- ABP:
- No Import Docs
- Immunogen:
- Kinase|RNA
- Extra Details:
- A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 uM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 uM. 3 Suppresses the SIRT1/CK2A Alpha pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
- Shipping Conditions:
- Ambient