10-1621
Dienamide A2
Size
£158.00
- SKU:
- 10-1621
- Physical State:
- Solid
- Molecular Weight:
- 251.41
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 24738-51-0
- Immunogen:
- GPCR
- Extra Details:
- Analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFA Alpha mRNA expression in human monocytes/macrophages via the CB2 receptor.1 Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive but not in CB2-negative cells and this effect was blocked by SR144528.2 It significantly inhibits LPS-induced TNFA Alpha and IL-1B Beta expression in a CB2-independent manner.2
- Shipping Conditions:
- Blue Ice