ST-034307

Size

£163.00

SKU:: 10-1620
Physical State:: Solid
Molecular Weight:: 297.95
Purity:: 98%
Storage Conditions:: RT
Supplier:: Focus Biomolecules
CAS Number:: 133406-29-8
Immunogen:: Adenylyl cyclase
Extra Details:: A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 uM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and GA Alphas-coupled receptors in HEK-AC1 cells. It enhanced u-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic u-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1