10-1608
Seriniquinone
Size
£158.00
- SKU:
- 10-1608
- Physical State:
- Solid
- Molecular Weight:
- 344.34
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 22200-69-7
- Extra Details:
- A new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin as determined using an immunoaffinity approach.1
- Shipping Conditions:
- Ambient