SMED-1

Size

£149.00

SKU:: 10-1606
Physical State:: Solid
Molecular Weight:: 372.89
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
Extra Details:: A dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at concentrations up to 850 uM. In contrast ALL-3 cells are sensitive to nanomolar concentrations of Dex (IC50=12 nM).2 SMED-1 displays strong synergism at 10 uM plus 1 uM Dex and exhibits little activity alone (IC50>20 uM). SMED-1 is Dex-synergistic in ALL-3, ALL-4 and ALL-16 xenografts but is antagonistic with ALL-31. Synergy is highest when drugs are given simultaneously.1