10-1579
4u8C
Size
£131.00
- SKU:
- 10-1579
- Physical State:
- Solid
- Molecular Weight:
- 204.18
- Purity:
- 97%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 14003-96-4
- Immunogen:
- RNA|Transcription factor|UPR (Unfolded Protein Response)
- Extra Details:
- Selective inhibitor of IRE1A Alpha ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1A Alpha and inactivating both XBP1 splicing and IRE1A Alpha-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1A Alpha in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic B Beta-cells4.
- Shipping Conditions:
- Ambient