10-1569
Dabrafenib
Size
£139.00
- SKU:
- 10-1569
- Additional Names:
- GSK2118436
- Physical State:
- Solid
- Molecular Weight:
- 519.56
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 1195765-45-7
- Immunogen:
- ER/Golgi|Kinase
- Extra Details:
- Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
- Shipping Conditions:
- Ambient