L524-0366

Size

£163.00

SKU:: 10-1536
Physical State:: Solid
Molecular Weight:: 308.79
Purity:: 98%
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 951612-19-4
Extra Details:: Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 uM). It specifically inhibits TWEAK-Fn14-mediated NFK KappaB activation. It completely suppressed TWEAK-induced T98G cell migration (10 uM) without cytotoxicity up to 50 uM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.