DC260126

Size

£147.00

SKU:: 10-1531
Physical State:: Solid
Molecular Weight:: 307.37
Purity:: 98%
Purification:: HPLC Purified
Storage Conditions:: -20[o]C
Supplier:: Focus Biomolecules
CAS Number:: 346692-04-4
Immunogen:: GPCR
Extra Details:: A GPR40 receptor antagonist1. Suppresses fatty acid-induced elevation of intracellular Ca++. Inhibits palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic B Beta cells in vitro. Lowers serum insulin levels, increases insulin sensitivity2 in obese Zucker rats (6 mg/kg)2. Reduces pancreatic B Beta cell apoptosis in obese diabetic (db/db) rats3. Protects Min6 B Beta cells from palmitic acid-induced ER stress and apoptosis4