10-1504
FLI-06
Size
£163.00
- SKU:
- 10-1504
- Physical State:
- Solid
- Molecular Weight:
- 438.52
- Purity:
- 98%
- Storage Conditions:
- -20[o]C
- Supplier:
- Focus Biomolecules
- CAS Number:
- 313967-18-9
- Immunogen:
- ER/Golgi
- Extra Details:
- FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 M).1 Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma.2 Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.3
- Shipping Conditions:
- Ambient